Don’t tighten screws all the way before checking the slope—you might get a puddle that becomes a moat for mosquitoes. And please, use sturdy galvanized or aluminum hangers; plastic ones will crack in a hailstorm and leave you asking existential questions.
Also, avoid the “I’ll do it alone on a windy day” trap. The gutter will fight you, the ladder will wobble, and your blood pressure will spike. Call a friend, wear gloves, and play some upbeat music.